METHOD FOR PREPARING IMPROVED CARDIOMYOCYTE-LIKE CELLS
摘要
The present invention relates to the field of cell differentiation. In particular, the present invention relates to a method for preparing improved cardiomyocyte-like cells differentiated from at least one multipotent or pluripotent cell, comprising a step of contacting the cardiomyocyte-like cell(s) with at least one agent to promote and/or induce integrin subunit alpha-V (integrin alphav) activity, thereby modulating expression of at least one cardiac gene of said cardiomyocyte-like cells. It also relates to a method for screening for an agent capable of improving cardiomyocytes differentiated from at least one multipotent or pluripotent cell.
申请公布号
WO2013085464(A1)
申请公布日期
2013.06.13
申请号
WO2012SG00457
申请日期
2012.12.06
申请人
SINGAPORE HEALTH SERVICES PTE LTD
发明人
SHIM, SE NGIE, WINSTON;YONG, JEAN AI, PEARLY;WONG, EN HOU, PHILIP