发明名称 |
NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (3) |
摘要 |
A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity.
[R 1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R 2 and R 3 represent hydrogen; R 4 , R 5 , R 6 , and R 7 may be the same or different and each represents hydrogen, halogen, C 1-6 alkyl or the like; R 8 represents hydrogen or the like; R 9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents -CH=, nitrogen or the like.] |
申请公布号 |
EP1889836(B1) |
申请公布日期 |
2013.06.12 |
申请号 |
EP20060796594 |
申请日期 |
2006.08.21 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
MATSUSHIMA, TOMOHIRO;TAKAHASHI, KEIKO;FUNASAKA, SETSUO;OBAISHI, HIROSHI;SHIROTORI, SHUJI |
分类号 |
C07D213/75;A61K31/4409;A61K31/496;A61K31/506;A61K31/5377;A61P35/00;A61P35/04;A61P43/00;C07D239/47;C07D401/12;C07D401/14 |
主分类号 |
C07D213/75 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|