发明名称 |
SEMI-DIGITAL LIGATION ASSAY |
摘要 |
Assays for detecting mutant sequences at particular locations, especially against a background of non-mutant sequences, employ thermocycling ligase reactions. Differentially labeled or sized probes can be used to distinguish wild-type and mutant sequences. Physico-chemical properties of the probes can be critical to successful detection. Mutation detection can be used for diagnosis, monitoring, or prognosticating diseases such as cancers. |
申请公布号 |
WO2013006791(A3) |
申请公布日期 |
2013.06.06 |
申请号 |
WO2012US45757 |
申请日期 |
2012.07.06 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;VOGELSTEIN, BERT;KINZLER, KENNETH W. |
发明人 |
VOGELSTEIN, BERT;KINZLER, KENNETH W. |
分类号 |
C12Q1/68;C12N15/11 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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