| 摘要 |
Disclosed herein are 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran compounds of formula I, wherein the substituents are as defined within the specification, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful as antimicrobial agents. Examples of particularly preferred compounds include: (1S)-1-{ (2S,5R)-5-[(6,7-dihydro-8-oxa-5-thia-1,2-diaza-naphthalen-3-ylmethyl)-amino]-tetrahydro-pyran-2-yl} -2-(3-fluoro-6-methoxy-[1,5]naphthyridin-4-yl)-ethanol; (1S)-1-{ (2S,5R)-5-[(2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)-amino]-tetrahydro-pyran-2-yl} -2-(6-methoxy-[1,5]naphthyridin-4-yl)-ethanol; (1S)-1-{ (2S,5R)-5-[(2,3-dihydro-4-oxa-1-thia-6-aza-naphthalen-7-ylmethyl)-amino]-tetrahydro-pyran-2-yl} -2-(3-fluoro-6-methoxy-[1,5]naphthyridin-4-yl)-ethanol; (1S)-1-{ (2S,5R)-5-[(6,7-dihydro-8-oxa-5-thia-1,2-diaza-naphthalen-3-ylmethyl)-amino]-tetrahydro-pyran-2-yl} -2-(3-fluoro-6-methoxy-[1,5]naphthyridin-4-yl)-ethanol; (1S)-1-((2S,5R)-5-(((2,3-dihydro-[1,4]dioxino-2,2,3,3-d4-[2,3-c]pyridin-7-yl)methyl)amino)tetrahydro-2H-pyran-2-yl)-2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethanol.
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