| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide compositions and methods for treating cancers and bone density abnormalities, including such agents that interfere or neutralize DKK1- and/or DKK4-mediated antagonism of Wnt signaling. <P>SOLUTION: Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition. <P>COPYRIGHT: (C)2013,JPO&INPIT |
