The present invention provides the identification and characterization of NOTCH mutations associated with enhanced receptor signaling. The present invention provides methods and kits for using the same. The present invention further provides methods of treating cancer in a patient having a solid tumor, wherein the solid tumor cells comprise an elevated level of NOTCH ICD.
申请公布号
WO2013074596(A1)
申请公布日期
2013.05.23
申请号
WO2012US64969
申请日期
2012.11.14
申请人
ONCOMED PHARMACEUTICALS, INC.
发明人
CAIN, JENNIFER, ANNE;WANG, MIN;KAPOUN, ANN, M.;HOEY, TIMOTHY, C.