Disclosed herein are enhanced polypeptides, polynucleotides encoding these polypeptides, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
申请公布号
WO2013074999(A1)
申请公布日期
2013.05.23
申请号
WO2012US65634
申请日期
2012.11.16
申请人
SANGAMO BIOSCIENCES, INC.
发明人
GREGORY, PHILIP D.;MILLER, JEFFREY C.;PASCHON, DAVID;REBAR, EDWARD J.;TAN, SIYUAN;URNOV, FYODOR;ZHANG, LEI