发明名称 |
AMIDE BASED GLUCAGON SUPERFAMILY PEPTIDE PRODRUGS |
摘要 |
Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
|
申请公布号 |
US2013123462(A1) |
申请公布日期 |
2013.05.16 |
申请号 |
US201113697021 |
申请日期 |
2011.06.14 |
申请人 |
DIMARCHI RICHARD D.;KOU BINBIN;INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION |
发明人 |
DIMARCHI RICHARD D.;KOU BINBIN |
分类号 |
C07K14/605 |
主分类号 |
C07K14/605 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|