Process and intermediates for preparing macrolactams
摘要
The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and methods described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. An example of an HCV inhibitory compound that can be synthesized using the procedures described herein is Compound A and derivative thereof.
申请公布号
AU2011344075(A1)
申请公布日期
2013.05.09
申请号
AU20110344075
申请日期
2011.12.13
申请人
MERCK SHARP & DOHME CORP.
发明人
CHEN, CHENG;KONG, JONGROCK;HUMPHREY, GUY;DOLMAN, SARAH;LI, HONGMEI;TUDGE, MATTHEW T.;YONG, KELVIN;XIANG, BANGPING;ZACUTO, MICHAEL