发明名称 TRANSDERMAL DELIVERY SYSTEM
摘要 <P>PROBLEM TO BE SOLVED: To provide transdermal delivery systems for administering sufentanil through the skin. <P>SOLUTION: The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer as an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided. <P>COPYRIGHT: (C)2013,JPO&INPIT
申请公布号 JP2013079281(A) 申请公布日期 2013.05.02
申请号 JP20130002422 申请日期 2013.01.10
申请人 DURECT CORP 发明人 YUM SU IL;THEEUWES FELIX
分类号 A61K31/4535;A61K9/70;A61P25/04 主分类号 A61K31/4535
代理机构 代理人
主权项
地址