METHOD AND DEVICE FOR EXAMINING MYOCARDIAL TOXICITY AND EVALUATING CARDIOMYOCYTE

摘要

A method wherein a mass of cardiomyocytes is disposed on a transparent substrate and the quality of the cardiomyocytes is evaluated from the response of the cardiomyocytes to a forced pulsation stimulus that is applied to the pulsating cardiomyocytes. The mass of cardiomyocytes, which is disposed on the transparent substrate, is exposed to the flow of a drug-containing liquid in such a manner as to allow the drug to act on cells configuring a network. The level of cardiotoxicity caused by the drug is evaluated by measuring the fluctuations obtained from a comparison of adjacent pulsating cardiomyocytes of the network.