发明名称 |
PROCESS FOR THE SULFINYLATION OF A PYRAZOLE DERIVATIVE |
摘要 |
<p>The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent S in the presence of at least one amine acid complex wherein the amine(s) are selected from secondary and/or tertiary amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent, wherein S is [CF3S(O)]2O; or CF3S(O)X wherein X means fluoro, chloro, bromo, iodo, a hydroxy group, or an alkaline or alkaline earth metal salt of the hydroxy group; or mixtures thereof, wherein the temperature of the reaction mixture at no time exceeds 39° C.</p> |
申请公布号 |
EP2084137(B1) |
申请公布日期 |
2013.04.24 |
申请号 |
EP20070822223 |
申请日期 |
2007.11.05 |
申请人 |
BASF AGRO B.V., ARNHEM (NL), ZUERICH BRANCH |
发明人 |
SUKOPP, MARTIN;KUHN, OLIVER;GROENING, CARSTEN;KEIL, MICHAEL;LONGLET, JON J. |
分类号 |
C07D231/44;A01N43/00;A01N43/56;A61K31/415;A61P33/00 |
主分类号 |
C07D231/44 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|