| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to medicine and pharmaceutical industry, and concerns a combined pharmaceutical composition with antibacterial and antifungal activity. The composition comprises clindamycin phosphate, butoconazole nitrate as active ingredients. As a basis, the composition comprises a combination of a hydrophobic ingredient, a hydrophilic ingredient and an emulsifier and a gelling agent. A method of preparing the declared composition involves that a solution of clindamycin salt or ester in a part of the hydrophilic ingredient is added with the gelling polymer, then the emulsion prepared of a solution of butoconazole in the remained part of the hydrophilic ingredient, the hydrophobic ingredient and the emulsifier, and the prepared mixture is agitated until smooth.EFFECT: new pharmaceutical composition is characterised by a high level of antibacterial and antifungal activity, stability both at the storage temperature (25°C), and at temperature of use (37°C), good packaging extrusion and high osmotic activity.13 cl, 1 tbl, 4 ex |
