发明名称 |
PROCESS FOR THE PREPARATION OF DIHYDROPYRROLE DERIVATIVES |
摘要 |
<p>The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R1 is chlorodifluoromethyl or trifluoromethyl; R2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R1 and R2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R1 and R2 are as defined for the compound of formula I; and (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).</p> |
申请公布号 |
EP2580211(A1) |
申请公布日期 |
2013.04.17 |
申请号 |
EP20110728598 |
申请日期 |
2011.06.14 |
申请人 |
SYNGENTA PARTICIPATIONS AG;SYNGENTA LIMITED |
发明人 |
EL QACEMI, MYRIEM;SMITS, HELMARS;CASSAYRE, JEROME YVES;MULHOLLAND, NICHOLAS PHILLIP;RENOLD, PETER;GODINEAU, EDOUARD;PITTERNA, THOMAS |
分类号 |
C07D207/46 |
主分类号 |
C07D207/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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