HIGH-TEMPERATURE AND HIGH-PRESSURE CROSS COUPLING METHOD

摘要

PROBLEM TO BE SOLVED: To provide a carbon-carbon coupling reaction method of an organic compound by utilizing a microreactor system provided with a high-pressure mixing means and a high-temperature and high-pressure reaction means and using high-temperature and high-pressure water.

SOLUTION: The carbon-carbon coupling reaction method of an organic compound according to a reaction process using high-temperature and high-pressure water as a reaction medium is provided, wherein while a reaction substrate which is solid at 25°C and 1 atm is dissolved in or mixed with a medium obtained by adding a quasi-solvent to water or while the reaction substrate is melted by heating, the substrate is subjected to reaction in a microreactor under the conditions of high-temperature and high-pressure water to form a carbon-carbon bond of the organic compound. Thus, the new carbon-carbon coupling reaction method is provided, which forms the carbon-carbon bond of the organic compound in a short time and with a high yield and high selectivity utilizing the high-temperature and high-pressure microreactor system.

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