发明名称 |
MICRORNA-CONTROLLED RECOMBINANT VACCINIA VIRUS AND USE THEREOF |
摘要 |
It is intended to provide a vaccinia virus that specifically proliferates in a cancer cell and destroys the cancer cell and to provide use of the virus in cancer treatment. The present invention provides a microRNA-controlled vaccinia virus, in which a target sequence of a microRNA less expressed in a cancer cell than in a normal cell is inserted in a 3′untranslated region of B5R gene associated with viral proliferation in a vaccinia virus, wherein the microRNA-controlled vaccinia virus specifically proliferates in the cancer cell and has an oncolytic property that destroys the cancer cell.
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申请公布号 |
US2013071430(A1) |
申请公布日期 |
2013.03.21 |
申请号 |
US201113639784 |
申请日期 |
2011.03.15 |
申请人 |
NAKAMURA TAKAFUMI;HIKICHI MINA;TAHARA HIDEAKI;SHIDA HISATOSHI;KIDOKORO MINORU;THE UNIVERSITY OF TOKYO |
发明人 |
NAKAMURA TAKAFUMI;HIKICHI MINA;TAHARA HIDEAKI;SHIDA HISATOSHI;KIDOKORO MINORU |
分类号 |
C12N7/00 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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