SUBSTITUTED AROMATIC UREA COMPOUND AND USE THEREOF AS ANTI-CANCER DRUG

摘要

The present invention relates to substituted aromatic urea compounds of formula (I) or (II) as VEGFR-2 kinase inhibitors, and use thereof in preparation of a drug for treating VEGFR-2 mediated diseases. R1, R2 and R3 are selected from halogen, cyan, hydroxyl, trifluoromethyl, methoxy, trifluoromethoxy, substituted or unsubstituted C1-C6 straight chain, C1-C6 branched chain alkyl, C3-C7 cycloalkyl, C6-C10 aryl, C6-C10 heteroaryl or one or more C6-C10 heterocyclic groups selected from N, S, O atoms; the substituent group is selected from amino, halogen, C1-C6 alkyl, hydroxyl, C1-C6 alkyloxy, nitro, cyan, sulfhydryl, C1-C6 alkylthio, halogen-C1-C6 alkylthio, heterocyclic group, heteroaryl, heterocyclic alkyl, heteroaryl C1-C6 alkyl, C1-C6 alkanoyl or carbamoyl.