| 摘要 |
The present invention aims to present methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect cognitive impairment including mild cognitive impairment and Alzheimer disease. Simultaneously, the present invention aims to present novel biomarkers for cognitive impairment and non-psychiatry disease and methods for detecting cognitive impairment using such biomarkers. Specifically, a biomarker for diagnosis of psychiatry disease or cognitive impairment comprising protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of amino acid sequence expressed by SEQ ID NO: 1, 3, 6, 8, 10, 13, 15, 18, and 20 and selected from the group of partial peptide in these proteins consisting of amino acid sequence expressed by SEQ ID NO: 2, 4, 5, 7, 9, 11, 12, 14, 16, 17, 19, and 21. And further aims to present diagnostic method using these biomarker, and further aims to present synthesis antigen peptide expressed by SEQ ID NO: 22 for preparation of peptide specific antibody for use in diagnostic method. |
