发明名称 |
Method of activation of oxazaphosphorines |
摘要 |
The present invention provides a method of hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug), by administering the compound of interest to the subject; and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxylate or oxidize the compound of interest in the subject.
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申请公布号 |
US8399434(B2) |
申请公布日期 |
2013.03.19 |
申请号 |
US20070375482 |
申请日期 |
2007.11.06 |
申请人 |
SPASOJEVIC IVAN;COLVIN MICHAEL O.;BATINIC-HABERLE INES;LUDEMAN SUSAN M.;GAMCSIK MICHAEL P.;DUKE UNIVERSITY |
发明人 |
SPASOJEVIC IVAN;COLVIN MICHAEL O.;BATINIC-HABERLE INES;LUDEMAN SUSAN M.;GAMCSIK MICHAEL P. |
分类号 |
A01N57/00;A61K31/675 |
主分类号 |
A01N57/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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