发明名称 |
Anti-tumor/cancer heterologous acellular collagenous preparations and uses thereof |
摘要 |
Disclosed are mammalian tumor and/or cancer cell conditioned substrate preparations having tumor inhibiting activity. In some embodiments, the mammalian tumor and/or cancer cell conditioned substrate preparations are essentially free of cellular components. These preparations comprise a conditioned heterologous acellular collagenous tissue preparation, and may be prepared using a mammalian extracellular matrix substrate. The conditioned substrates include many different anti-tumor and/or anti-cancer biomolecules, such as that population of anti-tumor biomolecules that are secreted and/or produced by mammalian tumor and/or cancer cells as they grow on a substrate, thus imparting the anti-tumor and/or anti-cancer properties to the conditioned substrates of the invention. The present disclosure also provides methods for preparing the mammalian tumor and/or cancer cell conditioned substrates, as well as methods for using the preparations to inhibit tumor growth, such as in a vaccine or wound dressing. Methods for inhibiting prostate tumors and melanoma with the described conditioned substrates are also described. The conditioned mammalian tumor and/or cancer cell substrate preparations are essentially free of viable and/or carcinogenic or invasive tumor and/or cancer cells. The conditioned substrates and substrate preparations include anti-tumor and anti-cancer properties that may be used in preparations and formulations for the treatment of cancer. |
申请公布号 |
AU2011302371(A1) |
申请公布日期 |
2013.03.14 |
申请号 |
AU20110302371 |
申请日期 |
2011.09.12 |
申请人 |
THE UNIVERSITY OF NOTRE DAME;COOK BIOTECH |
发明人 |
SUCKOW, MARK A.;HILES, MICHAEL C. |
分类号 |
A61K35/22;A61K39/00;A61L15/40;A61P35/00;C12N5/00 |
主分类号 |
A61K35/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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