| 摘要 |
<p>Disclosed in the present invention is a adefovir monoester and preparation method thereof, wherein the X-ray powder diffraction spectrum represented by degree 2T of the adefovir monoester has peaks at 3.60?3.96?6.00?12.66?13.20?14.38?15.40?15.80?16.26?16.78?17.84?18.10?18.60?19.84?20.74?24.28?24.56?26.42?28.70 using Cu-K a radiation; the melting point is 188-192°C. The preparation method of the adefovir monoester is: adefovir dipivoxil (AD) is dissolved in water or a mixed solvent of acetonitrile and water, then the mixture is stirred and warmed to 30-60°C, a weak base is added for hydrolysis, and the resulting mixture is concentrated under reduced pressure after reaction completion detected by HPLC, and the monoester is obtained as white fine product via treatment. The adefovir monoester prepared by the present invention has good quality, with purity up to above 99% by the HPLC normalization method.</p> |
