| 摘要 |
The invention relates to a method for determining the amount of conjugated taxane, in particular paclitaxel, in a PGA-taxane conjugate
said method comprising:
a) reacting the PGA-taxane conjugate with a compound formula (I):
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ R 1 R 2 N-NH 2 €ƒ€ƒ€ƒ€ƒ€ƒ(I)
wherein
R 1 and R 2 are as defined in the description;
to give a unbound taxane and a PGA hydrazide and
b) determining the amount of unbound taxane. |
