发明名称 |
CARBOCYANINES FOR G-QUADRUPLEX DNA STABILIZATION AND TELOMERASE INHIBITION |
摘要 |
Cyanines which selectively bind to G-quadruplex DNA complexes, particularly quadruplexes expressed in cancer cells, and methods of making and using thereof are described herein. The cyanine can be a symmetrical or unsymmetrical streptocyanine, hemicyanine, closed chain cyanine, or combinations thereof. The cyanine is preferably substituted with one or more groups that minimize or prevent aggregation of the cyanine and/or inhibit binding of the cyanine to duplex DNA. One or more of the cyanines can be formulated with one or more pharmaceutical excipients and/or carrier to prepare pharmaceutical compositions suitable for administration to a patient, particular a human patient. The compounds and compositions described herein can be used to treat diseases or disorders characterized by the expression of G-quadruplex DNA, such as cancer. |
申请公布号 |
WO2013012886(A1) |
申请公布日期 |
2013.01.24 |
申请号 |
WO2012US47118 |
申请日期 |
2012.07.18 |
申请人 |
GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.;HENARY, MAGED;WILSON, W., DAVID |
发明人 |
HENARY, MAGED;WILSON, W., DAVID |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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