| 发明名称 |
Antibodies to human programmed death receptor PD-1 |
| 摘要 |
Antibodies which block the binding of human Programmed Death Receptor 1 (hPD-1) to its ligands (hPD-L1 or hPD-L2) and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune response through the PD-I pathway is also disclosed. |
| 申请公布号 |
US8354509(B2) |
申请公布日期 |
2013.01.15 |
| 申请号 |
US20080663950 |
申请日期 |
2008.06.13 |
| 申请人 |
MSD OSS B.V.;CARVEN GREGORY JOHN;VAN EENENNAAM HANS;DULOS GRADUS JOHANNES |
发明人 |
CARVEN GREGORY JOHN;VAN EENENNAAM HANS;DULOS GRADUS JOHANNES |
| 分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
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