| 摘要 |
Provided herein are methods for treating pain and for reducing the excitability of nociceptors, comprising administering a TGF-&bgr; antagonist. In some embodiments, a TGF-&bgr; antagonist is a monoclonal TGF-&bgr; neutralizing antibody or a fusion product comprising a monoclonal TGF-&bgr; neutralizing antibody, a soluble receptor, an antisense oligodeoxynucleotides (ODNs), a ribozymes, a small inhibitory RNA (siRNA), Smad 6, Smad7, or a small molecule that blocks TGF-&bgr; signaling.
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