发明名称 |
Oral preparation comprising specific organic acid, and method for improvement in elution property and chemical stability of oral preparation |
摘要 |
<p>Disclosed is a chemically stable oral preparation having an excellent elution property, which comprises a specific morphinan derivative or a pharmacologically acceptable acid addition salt thereof as an active ingredient. Specifically disclosed is an oral preparation which comprises a specific morphinan derivative or a pharmacologically acceptable acid addition salt thereof as an active ingredient, and additionally contains such an organic acid that 30 mL or more of water is needed for dissolving 1 g of the organic acid at 20˚C. Also disclosed is a method for improving the elution property and the chemical stability of an oral preparation comprising a specific morphinan derivative or a pharmacologically acceptable acid addition salt thereof as an active ingredient, which comprises adding such an organic acid that 30 mL or more of water is needed for dissolving 1 g of the organic acid at 20˚C to the oral preparation.</p> |
申请公布号 |
AU2008254038(B2) |
申请公布日期 |
2013.01.10 |
申请号 |
AU20080254038 |
申请日期 |
2008.05.20 |
申请人 |
TORAY INDUSTRIES, INC. |
发明人 |
TOKUMITSU, HIROYUKI;OHTA, KOTOE;MINAKAMI, SATOSHI |
分类号 |
C07D489/02;A61K9/14;A61K9/20;A61K9/48;A61K31/485;A61K47/12;A61K47/16;A61P1/14;A61P13/02;A61P17/04;A61P25/04 |
主分类号 |
C07D489/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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