METHOD FOR PRODUCING L-ARGININE AND L-CITRULLINE WITH USE OF BACTERIA OF ENTEROBACTERIACEAE FAMILY WITH ATTENUATED pepA GENE EXPRESSION

摘要

FIELD: medicine.SUBSTANCE: what is described is a bacterium producing L-arginine and L-citrulline belonging to the Escherichia species, modified so that pepA gene expression modifying aminopeptidase A is attenuated. What is presented is a method for producing L-amino acid specified in L-arginine and L-citrulline involving culture of said modified bacteria in a nutrient medium for production and secretion of said L-amino acid in a culture fluid and recovery of said L-amino acid from the culture fluid.EFFECT: invention enables producing L-arginine and L-citrulline in the enlarged volume.3 cl, 2 dwg, 1 tbl, 3 ex