发明名称 |
METHODS OF TREATING AND PREVENTING GLUCOSE TOXICITY |
摘要 |
The present invention relates to a method for treating and/or preventing a disease associated with glucose toxicity in a subject which may comprise administering to the subject a compound that reduces the level of Bim, PUMA and/or Bax activity in a cell of the subject. Furthermore, provided is a method for culturing cells susceptible to exposure to high concentrations of glucose, which may comprise delivering to the cells, or progenitor cells thereof, a compound that reduces the level of Bim, PUMA and/or Bax activity in the cells. |
申请公布号 |
EP2331135(A4) |
申请公布日期 |
2013.01.02 |
申请号 |
EP20090804387 |
申请日期 |
2009.08.05 |
申请人 |
ST. VINCENT'S INSTITUTE OF MEDICAL RESEARCH;WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH |
发明人 |
STRASSER, ANDREAS;MCKENZIE, MARK;THOMAS, HELEN;ALLISON, JANETTE;KAY, TOM |
分类号 |
A61K39/395;A61K31/7088;A61K31/7105;A61K31/711;A61P3/10;A61P9/10;A61P13/12;A61P25/02 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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