METHODS FOR PRODUCING ANTIBODIES FROM PLASMA CELLS

摘要

Disclosed are methods of producing antibodies, including monoclonal antibodies, comprising culturing a limited number of plasma cells, i.e less than 100 and ideally 1-25. It also relates to methods of identifying antibodies by performing assays on the antibodies produced by the cultured plasma cells to determine their function, binding specificity, epitope specificity, and/or their ability to neutralize a toxin or a pathogen.