METHOD OF PRODUCING (C-CARBONYL)DIMETHYL PHTHALATE

摘要

FIELD: chemistry.SUBSTANCE: invention relates to a method of producing (C-carbonyl)dimethyl phthalate which can be used to produce (C-carboxy)phthalic acid. Both compounds can be used to produce a range of agents for tumour diagnosis and therapy. The disclosed method involves carbonylation of 1,2-dibromobenzene with carbon monoxideCO in methanol at temperature of 100-150°C, pressure of not more than 1.0 MPa, in the presence of a catalyst system containing palladium acetate and a phosphine ligand, taken in molar ratio of 1:0.5-1:10, in the presence of triethylamine or sodium acetate. The method enables to obtain a product with output of up to 94.5% with isotopic purity of up to 99.3%. Catalyst efficiency reaches 9.9 mol/mol-h. (C-carboxy)phthalic acid with isotopic purity of 99% can be obtained from the obtained product via acid hydrolysis.EFFECT: high output of the end product.2 cl, 5 ex