发明名称 |
IN VITRO SORTING METHOD |
摘要 |
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention. |
申请公布号 |
CA2295324(C) |
申请公布日期 |
2012.12.18 |
申请号 |
CA19982295324 |
申请日期 |
1998.06.29 |
申请人 |
MEDICAL RESEARCH COUNCIL |
发明人 |
GRIFFITHS, ANDREW;TAWFIK, DAN |
分类号 |
C12N15/09;C12Q1/68;C12N9/02;C12N11/04;C12N15/10;C12P1/00;C12P17/18;C12P21/00;C12Q1/00;C12Q1/32;C40B20/08;C40B30/00;G01N33/15;G01N33/50 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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