发明名称 |
FIBRILLATION-RESISTANT INSULIN AND INSULIN ANALOGUES |
摘要 |
A fibrillation-resistant insulin analogue may be a single-chain insulin analogue or a physiologically acceptable salt thereof, containing an insulin A chain sequence or an analogue thereof and an insulin B chain sequence or an analogue thereof connected by a polypeptide of 4-10 amino acids. The fibrillation-resistant insulin analogue preferably displays less than 1 percent fibrillation with incubation at 37° C. for at least 21 days. A single-chain insulin analogue displays greater in vitro insulin receptor binding than normal insulin while displaying less than or equal binding to IGFR than normal insulin. The fibrillation-resistant insulin may be used to treat a patient using an implantable or external insulin pump, due to its greater fibrillation resistance. |
申请公布号 |
US2012316107(A1) |
申请公布日期 |
2012.12.13 |
申请号 |
US201213472833 |
申请日期 |
2012.05.16 |
申请人 |
WEISS MICHAEL;CASE WESTERN RESERVE UNIVERSITY |
发明人 |
WEISS MICHAEL |
分类号 |
C07K14/62;A61K38/28;A61P3/08;C12N1/19;C12N1/21;C12N15/17;C12N15/63 |
主分类号 |
C07K14/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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