发明名称 |
METHOD TO DETECT PROSTATE CANCER IN A SAMPLE |
摘要 |
The present invention provides methods to detect prostate cancer by detecting the RNA encoded by PCA3. The disclosure provides a method for determining a predisposition, or presence of prostate cancer comprising: (a) contacting a sample with at least one oligonucleotide that hybridizes to a PCA3 polynucleotide; (b) detecting an amount of PCA3 and second prostate-specific polynucleotides; and (c) comparing the amount of PCA3 polynucleotide that hybridizes to the oligonucleotide to a predetermined cut off value, and determining the presence or absence of prostate cancer. Diagnostic kits are provided for detecting prostate cancer or the risk of developing same comprising: (a) at least one container means containing at least one oligonucleotide probe or primer that hybridizes to PCA3 (b) at least one oligonucleotide probe or primer that hybridizes with a second prostate specific nucleic acid; and (c) reagents for detecting PCA3 and the second prostate specific nucleic acid. |
申请公布号 |
US2012309001(A1) |
申请公布日期 |
2012.12.06 |
申请号 |
US201213470451 |
申请日期 |
2012.05.14 |
申请人 |
DIAGNOCURE INC. |
发明人 |
FRADET YVES;CHYPRE CAMILLE;PICHE LYSON;GARON GENEVIEVE |
分类号 |
C12Q1/68;G01N21/64;G01N21/76;G01N21/78 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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