CONTROLLED RELEASE SOLID DOSE FORMS

摘要

The present invention is directed to a solid dose form comprising a film coating composition encapsulating a core, wherein: (i) the core comprises an active ingredient comprising at least one of a pharmaceutical, veterinary, or nutraceutical active ingredient; (ii) the film coating composition comprises ethylcellulose and guar gum, wherein the guar gum has an apparent viscosity = 151.0 cps at a shear rate of 50 s-1 in a 1% aqueous guar gum solution measured rotationally at 20°C after 1 minute equilibration using a 6 cm acrylic cone (1°) on a cone -plate viscometer wherein the shear is ramped up linearly from 1 to 50 s-1 in 25 steps over 29 seconds; (iii) the dose form provides controlled release of the active ingredient; (iv) the guar gum is present in an amount greater than 5 wt% based on the weight of the guar gum and ethylcellulose; and (v) the dose form is ethanol resistant.