| 发明名称 |
CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY |
| 摘要 |
The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HW). |
| 申请公布号 |
US2012301427(A1) |
申请公布日期 |
2012.11.29 |
| 申请号 |
US201213358041 |
申请日期 |
2012.01.25 |
| 申请人 |
BRIDGER GARY;KALLER AL;HARWIG CURTIS;SKERLJ RENATO;BOGUCKI DAVID;WILSON TREVOR R.;CRAWFORD JASON;MCEACHERN ERNEST J.;ATSMA BEM;NAN SIQIAO;ZHOU YUANXI;SCHOLS DOMINIQUE;SMITH CHRISTOPHER D.;DI FLURI MARIA R.;GENZYME CORPORATION |
发明人 |
BRIDGER GARY;KALLER AL;HARWIG CURTIS;SKERLJ RENATO;BOGUCKI DAVID;WILSON TREVOR R.;CRAWFORD JASON;MCEACHERN ERNEST J.;ATSMA BEM;NAN SIQIAO;ZHOU YUANXI;SCHOLS DOMINIQUE;SMITH CHRISTOPHER D.;DI FLURI MARIA R. |
| 分类号 |
A61K31/4709;A01N43/42;A01N43/50;A01N43/52;A01N43/58;A01N43/60;A61K31/415;A61K31/435;A61K31/436;A61K31/437;A61K31/47;A61K31/4725;A61K31/4745;A61K31/495;A61K31/497;A61K31/498;A61K31/50;A61K31/502;A61K31/506;A61K31/5377;A61K38/18;A61K38/19;A61K38/20;A61P7/00;A61P7/06;A61P9/00;A61P17/02;A61P29/00;A61P31/04;C07D235/10;C07D235/14;C07D401/12;C07D401/14;C07D403/12;C07D413/14;C07D471/04;C07D471/06;C07D491/04;C07D491/052;C12N;C12N5/0775;C12N5/0789 |
主分类号 |
A61K31/4709 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
