摘要 |
<p>The present invention provides for bicyclic heterocyclic compounds as PI3 kinase inhibitors e.g., PI3 kinase alpha, capable of covalently reacting with the kinase protein through binding to a PI3'kinase cysteine residue leading to the formation of a conjugate product, as well as methods utilizing such PI3 kinase inhibitors for treating a disease condition associated with the PI3-kinase in a subject.</p> |