摘要 |
The present invention is directed to a novel process for the preparation of compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof; comprising: reacting a compound of formula (V) wherein LG1 is a leaving group, with a mixture of a zinc salt and an organo-lithium reagent; in a first hydrocarbon solvent; at a temperature in the range of from about -78°C to about room temperature; to yield a mixture of the corresponding compound of formula (VI), wherein M1 is lithium, and the zinc salt; admixing to the mixture of the compound of formula (VI) and the zinc salt, a first ether solvent; to yield the corresponding compound of formula (VII), wherein M2 is a reactive zinc species. |
申请人 |
JANSSEN PHARMACEUTICA NV;HOUPIS, IOANNIS, NICOLAOS;LEMAIRE, SEBASTIEN, FRANCOIS, EMMANUEL |
发明人 |
HOUPIS, IOANNIS, NICOLAOS;LEMAIRE, SEBASTIEN, FRANCOIS, EMMANUEL |