发明名称 |
Non-viral delivery of compounds to mitochondria |
摘要 |
A conjugate comprises: (a) a mitochondrial membrane-permeant peptide; (b) an active agent or compound of interest such as a detectable group or mitochondrial protein or peptide; and (c) a mitochondrial targeting sequence linking said mitochondrial membrane-permeant peptide and said active mitochondrial protein or peptide. The targeting sequence is one which is cleaved within the mitochondrial matrix, and not cleaved within the cellular cytoplasm, of a target cell into which said compound is delivered. Methods of use of such compounds are also described. |
申请公布号 |
US8283444(B2) |
申请公布日期 |
2012.10.09 |
申请号 |
US20040972222 |
申请日期 |
2004.10.22 |
申请人 |
PAYNE R. MARK;WAKE FOREST UNIVERSITY |
发明人 |
PAYNE R. MARK |
分类号 |
C07K1/00;A61K35/00;A61K38/00;A61K38/44;A61K39/21;A61K39/395;A61K47/48;C07H21/02;C07H21/04;C07K;C07K5/00;C07K14/00;C07K14/47;C12N15/11;C12N15/63 |
主分类号 |
C07K1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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