发明名称 |
TUMOR-SPECIFIC BACTERIAL PROMOTER ELEMENTS |
摘要 |
The invention relates to bacterial promoter elements which constitute or which are comprised in promoter regions and which confer tumour specificity to the promoter region activity, resulting in transcription of a transgene, which can be a heterologous or a homologous gene, which transgene is functionally arranged downstream of the promoter region at presence of a host bacterium in tumour tissue, while essentially conferring inactivity of the promoter region and no transcription at presence of the host bacterium in non-tumour tissue. Accordingly, the invention relates to bacterial promoter regions containing these tumour specific promoter elements. |
申请公布号 |
US2012244621(A1) |
申请公布日期 |
2012.09.27 |
申请号 |
US201013321777 |
申请日期 |
2010.05.28 |
申请人 |
WEISS SIEGFRIED;BARTELS SARA;LOESSNER HOLGER;DEYNEKO IGOR;BUMANN DIRK;WESTPHAL-DANIEL KATHRIN;HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH |
发明人 |
WEISS SIEGFRIED;BARTELS SARA;LOESSNER HOLGER;DEYNEKO IGOR;BUMANN DIRK;WESTPHAL-DANIEL KATHRIN |
分类号 |
C12N1/21;C12N15/70;C12N15/74 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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