| 摘要 |
This invention features, in one aspect, mutant CD4 polypeptides. For example, described herein are polypeptides that include or consist of an amino acid sequence conforming to Formula I: Xaa1-Arg-Xaa2-Leu-Xaa3-Asp-Gln (SEQ ID NO:1), where Xaa1 is any amino acid residue; Xaa2 is any amino acid residue; and Xaa3 is Trp, Phe, or Tyr; with the proviso that the polypeptide is not a wild type CD4 protein or a fragment thereof (i.e., with the proviso that the polypeptide is not a fragment of a wild type CD4 protein).The mutant residue can be cysteine or selenocysteine. Other mutants, protein complexes, nucleic acids, vectors, and methods of use are also described. |
