QUATERNARY AMMONIUM SALT COMPOUNDS, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF

摘要

Quaternary ammonium salt compounds of general formula (I), the preparation method thereof, the pharmaceutical composition comprising compounds as the active components, and the use of compounds in the preparation of medicaments for treating diseases associated with Lp-PLA2 enzymic activity are provided in the present invention. In general formula (I), R1, R2, R3 are independently C1-4 alkyl, or R1 is C1-4 alkyl, R2 and R3 are taken together to form C4-5 alkylidene groups, X is F, Cl, Br or I.