发明名称 |
USE OF PROTEINS AND PEPTIDES ENCODED BY GENOME OF NOVEL SARS-ASSOCIATED CORONAVIRUS STRAIN |
摘要 |
<P>PROBLEM TO BE SOLVED: To provide: a protein and peptide encoded by a genome of isolated or purified strain of coronavirus associated with severe acute respiratory syndrome (SARS); and especially protein S and an antibody derived from the same, as a diagnostic reagent and as a vaccine. <P>SOLUTION: A recombinant expression vector encodes an ectodomain of S protein having a specific sequence or S protein composed of amino acids corresponding to 1-1193 position or 14-1193 position of specific sequence and contains a splice signal sequence and, optionally, WPRE sequence of woodchuck hepatitis virus (post-transcriptional regulatory element of woodchuck hepatitis virus) or CTE sequence of Mason-Pfizer simian retrovirus (constitutive transport element). The immunogenicity and/or a vaccine composition includes the recombinant vector. <P>COPYRIGHT: (C)2012,JPO&INPIT |
申请公布号 |
JP2012165750(A) |
申请公布日期 |
2012.09.06 |
申请号 |
JP20120091153 |
申请日期 |
2012.04.12 |
申请人 |
INST PASTEUR;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIV PARIS 7 |
发明人 |
VAN DER WERF SYLVIE;ESCRIOU NICOLAS;CRESCENZO-CHAIGNE BERNADETTE;MANUGUERRA JEAN-CLAUDE;KUNST FREDERIK;CALLENDRET BENOIT;BETTON JEAN-MICHEL;LORIN VALERIE;GERBAUD SYLVIE;BURGUIERE ANA MARIA;AZEBI SALIHA;CHARNEAU PIERRE;TANGY FREDERIC;COMBREDET CHANTAL;DELAGNEAU JEAN-FRANCOIS;MARTIN MONIQUE |
分类号 |
C12N15/09;A61K39/215;A61P11/00;A61P31/12;C07K14/165;C12N1/15;C12N1/19;C12N5/10;C12N7/00;C12P21/02;G01N33/569 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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