发明名称 Use of histamine H4 antagonist for the treatment of post-operative tissue adhesions after surgical procedures
摘要 <p>The disclosure relates to the use of a histamine H4 receptor antagonist in the preparation of a medicament for the inhibition of post-operative adhesion formation in a body between tissue surfaces in a body cavity having been subjected to a surgical procedure, which involve administering a histamine H4 receptor antagonist, systemically, directly to tissue surfaces in the body cavity, or both, and to delivery vehicles and compositions suitable for use for local, non-systemic administration of a drug to the body and directly to tissue within a body cavity having been subjected to a surgical procedure, wherein the medicament is formulated for systemic administration and wherein the at least one histamine H4 receptor antagonist is selected from the group consisting of:(a) benzoimidazolyl and benzoxazolyl amides and thioamides; (b) 8-membered bicyclic aromatic amides and thioamides; (c) 9-membered bicyclic aromatic amides, thioamides, and imides;(d) indolyl and benzimidazolyl pyrrolidinyl amides; pharmaceutically acceptable salts, hydrates, solvates and mixtures of any of said histamine H4 receptor antagonists.</p>
申请公布号 NZ589531(A) 申请公布日期 2012.08.31
申请号 NZ20090589531 申请日期 2009.06.11
申请人 JANSSEN PHARMACEUTICA N.V. 发明人 THURMOND, ROBIN, L
分类号 A61K39/395;A61K31/4184;A61K31/4439;A61K31/519;A61K45/06;A61L31/16;C07K16/28 主分类号 A61K39/395
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