发明名称 |
Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
摘要 |
The present invention relates to [1- (benzyl) -piperidin-4-yl] -( [1, 3,4] thiadiazol-2-yl) - amine and [1- (benzyl) -piperidin-4-yl] - (thiazol-2-yl) -amine derivatives of formula (I) that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects. |
申请公布号 |
AU2008240729(B2) |
申请公布日期 |
2012.08.23 |
申请号 |
AU20080240729 |
申请日期 |
2008.04.18 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
MACDONALD, GREGOR JAMES;BARTOLOME-NEBREDA, JOSE MANUEL;VAN GOOL, MICHIEL LUC MARIA |
分类号 |
C07D417/12;A61K31/454;A61P25/18 |
主分类号 |
C07D417/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|