发明名称 |
METHODS OF IDENTIFYING ANTI-INFLAMMATORY COMPOUNDS |
摘要 |
A mammalian C-type lectin receptor type is identified which is shown to bind IgG antibodies or Fc fragments, thus inducing WIG-related reversal of inflammation associated with various immune disorders. The identification of a DC-SIGN receptor type which interacts with IgG to promote a biological response reducing inflammation associated with immune disorders provides for methods of screening and selecting compounds which may be useful in treating various immune disorders by acting to modulate a DC-SIGN(+) cell to signal a second effector macrophage, causing an increase in expression of the FcγRIIB receptor and in turn inhibiting a cellular-mediated inflammatory response. |
申请公布号 |
US2012190619(A1) |
申请公布日期 |
2012.07.26 |
申请号 |
US201013496150 |
申请日期 |
2010.09.08 |
申请人 |
RAVETCH JEFFREY V.;ANTHONY ROBERT;THE ROCKEFELLER UNIVERSITY |
发明人 |
RAVETCH JEFFREY V.;ANTHONY ROBERT |
分类号 |
A61K38/19;A61P37/06;C07K1/14;C12N5/02;G01N21/64;G01N33/483;G01N33/50;G01N33/53 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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