METHODS FOR PREDICTING AND TREATING INFECTION-INDUCED ILLNESSES AND PREDICTING THE SEVERITY OF INFECTION-INDUCED ILLNESSES

摘要

The disclosure provides methods for determining or identifying a subject with an increased propensity to develop one or more infection- induced illness(es) or one or more severe infection-induced illness(es), as well as methods of treating an infection. Specifically, the methods require the steps of measuring the amount of a microbial nucleic acid or peptide and the amount of mitochondrial nucleic acid or peptide in the sample, and comparing the amount of the microbial nucleic acid or peptide to the amount of the mitochondrial nucleic acid or peptide. Also provided are kits containing one or more primers effective for the amplification of a mitochondrial nucleic acid and one or more primers effective for the amplification of a microbial nucleic acid, or one or more antibodies that specifically bind to one or more microbial peptides and one or more antibodies that specifically bind to one or more mitochondrial peptides for diagnosis.