PEGYLATED GEMCITABINE DERIVATIVE AND PROCESS FOR PREPARING THE SAME

摘要

According to this invention, a water soluble polymeric drug formulation is provided comprising the amphiphilic polymer conjugated to the amino group of gemcitabine. In accordance with this invention there is also provided a process for the preparation of water soluble polymeric drug formulation comprising the steps of: (a) providing an N-hydroxysuccinirnide ester of PEG by reaction of the carboxyl group of PEG with NHS in presence of EDC as a catalyst; (b) conjugation of the said polymer with the amine group of the gemcitabine.