EPIGENETIC BIOMARKERS FOR LIVER DISEASE

摘要

Methods are provided for identifying a hepatic cell exhibiting unregulated growth associated with methylation-silenced transcription of a carbamoyl phosphate synthetase 1 (CPS1) gene. In addition, methods of treating a cancer patient, wherein cancer cells in the patient exhibit methylation-silenced transcription of carbamoyl phosphate synthetase 1 (CPS1), are provided, as are reagents for practicing such methods. Additional methods are provided for identifying a colon cell exhibiting unregulated growth associated with transcription of a carbamoyl phosphate synthetase 1 (CPS1) gene. In addition, methods of treating a cancer patient, wherein colorectal cancer cells in the patient exhibit transcription of carbamoyl phosphate synthetase 1 (CPS1), are provided, as are reagents for practicing such methods.