| 发明名称 |
CAMPTOTHECIN DERIVATIVES |
| 摘要 |
Various 14-Nitro, 14-amino, and 14-substituted amino camptothecin derivatives are useful in the treatment of cancer and other hyperproliferative diseases. Various 14-nitro camptothecin derivatives are conveniently prepared by reacting a camptothecin derivative with fuming nitric acid, optionally employing acetic anhydride as a solvent. |
| 申请公布号 |
US2012165522(A1) |
申请公布日期 |
2012.06.28 |
| 申请号 |
US201013378662 |
申请日期 |
2010.06.16 |
| 申请人 |
CAI XIAOHONG;DUAN JIAN-XIN;MATTEUCCI MARK;CAO YEYU;JIAO HAILONG;THRESHOLD PHARMACEUTICALS, INC. |
发明人 |
CAI XIAOHONG;DUAN JIAN-XIN;MATTEUCCI MARK;CAO YEYU;JIAO HAILONG |
| 分类号 |
A61K31/4745;A61K31/496;A61K31/5377;A61P35/00;C07D491/22;C12N5/02 |
主分类号 |
A61K31/4745 |
| 代理机构 |
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