发明名称 |
Bridged artificial nucleoside and nucleotide |
摘要 |
Provided is a novel molecule for an antisense by which the expression of a specific gene can be efficiently regulated. As formulae (I) and (II) show, the novel artificial nucleoside has an amide bond introduced into a bridged structure of 2',4'-BNA/LNA. An oligonucleotide containing this 2',4'-bridged artificial nucleotide has a binding affinity for a single-stranded RNA comparable to that of publicly known 2',4'-BNA/LNA, and a resistance to nuclease stronger than that of LNA. Since the binding affinity of the aforesaid oligonucleotide to a single-stranded RNA is much stronger than that of S-oligo, in particular, it is expected that the oligonucleotide is applicable to nucleic acid drugs. |
申请公布号 |
AU2010312751(A1) |
申请公布日期 |
2012.06.14 |
申请号 |
AU20100312751 |
申请日期 |
2010.10.19 |
申请人 |
OSAKA UNIVERSITY |
发明人 |
OBIKA, SATOSHI;HARI, YOSHIYUKI;KODAMA, TETSUYA;YAHARA, AIKO;NISHIDA, MASARU |
分类号 |
C07H19/06;A61K31/712;C07H19/16;C07H21/00 |
主分类号 |
C07H19/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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